Key result
Life-threatening VF and SCA occur unexpectedly in young asymptomatic patients with Duchenne muscular dystrophy.
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Highlights that life-threatening ventricular fibrillation can occur unexpectedly in young, asymptomatic patients with Duchenne muscular dystrophy.
A previously asymptomatic 7-year-old boy with Duchenne muscular dystrophy unexpectedly developed sudden cardiac arrest with no preceding illness. An automated external defibrillator confirmed the presence of ventricular fibrillation. Cardiac MRI showed prominent myocardial fibrosis with no evidence of acute inflammation. Whole exome sequence revealed no associated pathological variance for lethal ventricular arrhythmias. Life-threatening ventricular fibrillation can occur in young patients with Duchenne muscular dystrophy.
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Mhanna et al. (2026) studied this question. Life-threatening ventricular fibrillation and sudden cardiac arrest can occur unexpectedly in young, asymptomatic patients with Duchenne muscular dystrophy.
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