The determination of biological and chemical factors is important to public health. Herein, we present a metal–organic framework (MOF)-assisted tunable copper hyperprobe (MATCH) for the dynamic on-site detection of diverse targets, including nucleic acids, proteins, antibiotics, and ions. MATCH is synthesized in an ultrafast and mild process by utilizing a MOF to assist mercaptosuccinic acid in capping and reducing Cu2+ into a composite hybrid. It exhibits high color-responsiveness to metal ions and hydrogen peroxide. Subsequently, catalase (CAT) is encapsulated within the MOF, forming a CAT@MOF complex, which not only enhances stability and activity but also acts as a signal transducer in MATCH. Through integration with clustered regularly interspaced short palindromic repeats/Cas or immune recognition, the CAT@MOF-mediated MATCH sensor exhibits greater sensitivity and efficiency than gold-standard sensors and remarkably reduces instrument dependence and analysis costs. MATCH provides a multiresponse to H2O2, metal ions, nucleic acids, proteins, and antibiotics, which holds great promise for in vitro diagnostics, food safety, and environmental monitoring, thus advancing public health protection.
Feng et al. (2026) studied this question.