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April 3, 2026Scientific ReportsOpen Access

Hyaluronic Acid–Phospholipid Hybrid Nanocarriers (Hyalutocosomes) for Enhanced Dermal Delivery of Vitamin E and Photoprotection

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Authors

MZMariam ZewailAEAmr ElkelishAEAbeer M. Elsayed

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Overview

Demonstrates improved delivery of vitamin E for photoprotection in skin, suggesting a promising approach for anti-photoaging.

Key Points

  • The aim is to develop an efficient system for delivering vitamin E to the skin to combat UV-related damage.
  • Developed vitamin E-loaded hyalutocosomes
  • Incorporated hyalutocosomes into collagen/vitamin C nanogel
  • Characterized size and encapsulation efficiency of nanocarriers
  • Evaluated effectiveness in a UVB-irradiated rat model
  • Hyalutocosomes showed approximately 99% encapsulation efficiency
  • Restored antioxidant enzyme levels significantly toward normal
  • Reduced UVB-induced inflammation markers (IL-6, TNF-α, MMP-9)
  • Improved skin histology compared to free vitamin E and blank gel

Cite This Study

Zewail et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e2e5a333a821460c4f0https://doi.org/10.1038/s41598-026-41623-y
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