Answers are grounded in this paper and cite their sources.
Demonstrates the synthesis of α-aminonitriles in a DNA-compatible manner, suggesting broader applications in combinatorial chemistry.
We report a DNA-compatible synthesis of α-aminonitriles via the Strecker reaction. Systematic optimization of reaction conditions and evaluation of a broad range of aldehydes and aromatic amines revealed high functional-group tolerance, with 68% of the examined substrates affording ≥ 70% conversion. The transformation proceeds under mild conditions that preserve DNA integrity, enabling multicycle split-and-pool library synthesis. This method expands the repertoire of DNA-compatible multicomponent reactions and enables the incorporation of α-aminonitrile scaffolds into DEL platforms.
No takes yet. Share an insight, caveat, or question.
Ryzhikh et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: