Randomized clinical trial demonstrates fMRI-guided TMS reduces PTSD symptoms, suggesting improved treatment personalization.
Transcranial magnetic stimulation (TMS) has shown promise in reducing posttraumatic stress disorder (PTSD) symptoms, with varied clinical results. A mechanistic understanding is needed to personalize treatment and improve response rates. The threat neurocircuitry, specifically the right amygdala, has consistently been implicated in PTSD pathophysiology. This neuroscience-informed trial aimed to modulate the threat neurocircuitry using functional MRI (fMRI)–guided TMS to treat PTSD.
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Rooij et al. (2026) studied this question.
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