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March 31, 2026Brain and BehaviorOpen Access

Anshen Jieyu Decoction: A Promising Remedy for Depression via AKT/mTOR Pathway Modulation in CUMS Rats

Zhen Li Zijun Ji Zehao Zhang Xuzhang Wang Hongyue Yu Dongrun Yang Huijin Zhang Y Liu Zhuxin Sui

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Key Points

This research investigates the effects of Anshen Jieyu Decoction on depression and its underlying mechanisms in a rat model of chronic stress.
Utilized CUMS (chronic unpredictable mild stress) model in rats to induce depression-like behavior.
Administered Anshen Jieyu Decoction to evaluate its effects on behavioral deficits.
Assessed biochemical markers including AKT and mTOR phosphorylation and HPA axis activity.
Anshen Jieyu Decoction improved behavioral deficits in CUMS-induced rats.
Treatment reduced hyperactivity of the hypothalamic-pituitary-adrenal axis.
Increased phosphorylation of AKT and mTOR was observed, indicating pathway activation.
Neuronal damage in hippocampus was significantly reduced.

Implication

A study reveals Anshen Jieyu Decoction reduces depression symptoms in CUMS rats, suggesting therapeutic potential for mood disorders.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e5f5a333a821460cbb7 https://doi.org/10.1002/brb3.71380

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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5The PI3K/AKT/NRF2 Signaling Pathway Involved in the Improvement of CUMS-Induced Depressive-like Behaviors by ApigeninOriginal Research · 2026 · 3 citations

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