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April 3, 2026CNS Neuroscience & Therapeutics2 citationsOpen Access

Targeting Ferroptosis Pathways for Synaptic Protection in Sevoflurane‐Induced Cognitive Impairment: A Nanomedicine Approach

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BZBin ZhaoCWChangming WangMZM Zhang

Key Points

  • This research aims to explore how targeting ferroptosis can protect synapses and enhance cognitive recovery in postoperative cognitive dysfunction (POCD).
  • Investigated ferroptosis mechanisms in synaptic dysfunction
  • Evaluated nanomedicine strategies for therapeutic targeting
  • Assessed cognitive outcomes related to synaptic protection
  • Targeting ferroptosis pathways showed potential to improve cognitive function
  • Nanomedicine approaches reduced markers of synaptic dysfunction
  • Further optimization of these strategies is necessary for clinical use

Abstract

Ferroptosis is a key mechanism driving synaptic dysfunction and cognitive decline in POCD. Targeting ferroptotic pathways using nanomedicine-based strategies holds considerable promise for mitigating POCD and promoting cognitive recovery. Further research is needed to optimize these therapeutic approaches for clinical application in POCD management.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e865a333a821460cec6https://doi.org/10.1002/cns.70850
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