PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
April 3, 2026International Journal of Vascular MedicineOpen Access

Single‐Nucleotide Polymorphisms Associated With Aortic and Varicose Vein–Related Vascular Anomalies: A Systematic Review

View Full Paper
Ask AI
Bookmark
Share

Authors

MVMarlies VerleyenYHYukun HeBCBert Callewaert

Discussion

Loading...

Member takes

Overview

Systematic review reveals SNP associations with vascular anomalies, highlighting genetic influences on disease susceptibility.

Key Points

  • To systematically review associations between single-nucleotide polymorphisms and vascular anomalies.
  • Conducted a systematic review following PRISMA guidelines.
  • Searched databases including PubMed, Embase, Web of Science, and Cochrane Library.
  • Included studies were assessed for quality using STREGA criteria and risk of bias with the Q-Genie tool.
  • Included 95 studies reporting 697 SNPs, predominantly intronic or regulatory variants.
  • Strongest associations found for aortic disease and varicose veins, with notable effect sizes for specific SNPs.
  • Gene Ontology analysis highlighted enrichment in pathways related to blood vessel formation and development.

Cite This Study

Verleyen et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e865a333a821460cf94https://doi.org/10.1155/ijvm/5345163
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enrichment of Rare Variants in Loeys–Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia2020 · 46 citations
  2. 2dbSNP: the NCBI database of genetic variation2001 · 7,937 citations
  3. 3The AORTA Gene score for detection and risk stratification of ascending aortic dilation2024 · 30 citations
  4. 4Gene panel sequencing in heritable thoracic aortic disorders and related entities – results of comprehensive testing in a cohort of 264 patients2015 · 81 citations
  5. 52022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines2022 · 1,993 citations