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April 3, 2026SeparationsOpen Access

Comprehensive Discovery and Characterization of Chemical Constituents in Huangqintang Decoction Using Off-Line Two-Dimensional Liquid Chromatography and High-Resolution Mass Spectrometry

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Authors

YFYan FangYNYi NanXTXijie Tian

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Overview

Demonstrates enhanced identification of chemical compounds in Huangqintang Decoction, suggesting improved analysis for traditional medicines.

Key Points

  • The aim is to comprehensively identify and characterize the chemical constituents in Huangqintang Decoction.
  • Developed off-line two-dimensional liquid chromatography coupled with UHPLC-Q-TOF/MS.
  • Differentiated isomers of flavonoid glycosides and triterpenoid saponins using specific mass spectra techniques.
  • Analyzed the complete chemical profile of HQD to address limitations of traditional methods.
  • Identified a total of 192 compounds including 88 flavonoids and 80 triterpenoids.
  • Demonstrated significant enhancement in chromatographic resolution for complex extracts.
  • Successfully differentiated some structurally related isomers based on mass spectral characteristics.

Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e865a333a821460cfb0https://doi.org/10.3390/separations13040110
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