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This research investigates the chemical behavior and interactions of IOX1 in solution, particularly with essential metal ions and albumin.

April 3, 2026Dalton Transactions0 citationsOpen Access

Interactions of IOX1, a histone demethylase inhibitor, with essential metal ions, albumin, and its clay-based nanoformulation

HKHilda KovácsUniversity of Szeged ODOrsolya DömötörUniversity of Szeged AGAnett GiriczUniversity of Szeged

Key Points

This research investigates the chemical behavior and interactions of IOX1 in solution, particularly with essential metal ions and albumin.
Characterization of IOX1 in aqueous solution
Analysis of complex formation with metal ions
Evaluation of interactions with albumin
Assessment of nanoformulation properties
IOX1 shows strong interactions with specific metal ions
Complex formation equilibria were established
The clay-based nanoformulation enhances the stability of IOX1
Interactions with albumin were characterized, suggesting potential for drug delivery.

Abstract

Herein, the chemical properties of 5-carboxy-8-hydroxyquinoline (IOX1), a histone lysine demethylase KDM4 inhibitor, were comprehensively characterized in aqueous solution, including its complex formation equilibria with essential metal ions such as...

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