What question did this study set out to answer?

This investigation aims to explore the effects of problematic evidence on clinical practice guidelines and subsequent patient outcomes.

April 3, 2026Open Access

Investigating the impact of problematic evidence on clinical practice guidelines and associated patient outcomes (VITALITY Study II): protocol

Key Points

This investigation aims to explore the effects of problematic evidence on clinical practice guidelines and subsequent patient outcomes.
Analyse existing literature on clinical practice guidelines.
Evaluate the influence of evidence on patient care decisions.
Identify shortcomings in current clinical guidelines.
Highlight gaps in evidence that affect guidelines.
Demonstrate potential negative impacts on patient outcomes.
Suggest recommendations for improving evidence use in guidelines.

Abstract

Formal ethical approval is not necessary for this study as it does not involve human or animal participants, nor does it involve the collection of primary data. We will disseminate the findings through publication in peer-reviewed journals and, whenever possible, presentations at academic conferences.

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Discussion

Authors

Chang Xu

Naval University of Engineering

Luis Furuya Kanamori

The University of Queensland

Huấn Cao

Hebei Medical University

Journals

BMJ Open

Actions

Institutions

University of Minnesota

University of Arizona

The University of Queensland

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Investigating the impact of problematic evidence on clinical practice guidelines and associated patient outcomes (VITALITY Study II): protocol

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study