Ginsenoside compound K modulates macrophage polarization to improve outcomes in ulcerative colitis, suggesting new treatment strategies.
GCK regulates the M1/M2 balance of macrophages through the GR-HADHB-FAO axis, thereby alleviating UC. This study reveals for the first time a novel mechanism by which GCK regulates macrophage polarization through metabolic reprogramming, offering a new potential therapeutic target and candidate drug for the clinical treatment of UC.
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Liu et al. (2026) studied this question.
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