Global prevalence of functional constipation across all age groups according to Rome II–IV criteria, 1999-2025: a systematic review and meta-analysis

Key Points

• The aim is to assess the global prevalence of functional constipation across different age groups using the Rome criteria.
• Conducted a systematic review and meta-analysis of studies from 1999 to 2025
• Utilized Rome II–IV diagnostic criteria for functional constipation
• Analyzed data across various populations by age and region
• Identified substantial global variation in functional constipation prevalence
• Found differences based on age, sex, and geographic location
• Emphasized the importance of standardized assessments for clinical and public health