Impact of the three-fold channel substitution D131N on kinetics of translocation of Fe ²⁺ across the protein coat is more severe for human cytosolic H-chain ferritin than for human mitochondrial ferritin.

Zinnia Bugg; Charlie Lewis Phillips Hazlewood; Andrew M. Hemmings; Justin Michael Bradley; Nick E. Le Brun

doi:10.1039/d5dt02739j

January 1, 2026Dalton TransactionsOpen Access

Impact of the three-fold channel substitution D131N on kinetics of translocation of Fe ²⁺ across the protein coat is more severe for human cytosolic H-chain ferritin than for human mitochondrial ferritin.

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Key Points

The aim is to investigate how the D131N substitution affects iron translocation kinetics in different types of human ferritin.
Comparison of the kinetics of iron translocation across cytosolic and mitochondrial ferritin.
Analysis of the functional performance of ferritin variants with D131N substitution.
Utilization of kinetic modeling to assess iron loading and release dynamics.
The D131N substitution significantly impairs iron translocation in human cytosolic H-chain ferritin.
Effects on human mitochondrial ferritin are less severe compared to the cytosolic variant.
Observations suggest differential regulatory mechanisms for iron management in cytosolic and mitochondrial ferritin.

Implication

Demonstrates the effects of D131N substitution on iron translocation in human ferritin, implying varying severity in different ferritin types.

Abstract

Ferritins play a key role in iron management in organisms from all kingdoms of life. Excess iron is sequestered in mineral form within the hollow protein shell and can be...

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Bugg et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f305a333a821460e1da https://doi.org/10.1039/d5dt02739j

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Impact of the three-fold channel substitution D131N on kinetics of translocation of Fe ²⁺ across the protein coat is more severe for human cytosolic H-chain ferritin than for human mitochondrial ferritin.

Key Points

Implication

Abstract

Discussion

Cite This Study

Impact of the three-fold channel substitution D131N on kinetics of translocation of Fe ²⁺ across the protein coat is more severe for human cytosolic H-chain ferritin than for human mitochondrial ferritin.

Key Points

Implication

Abstract

Discussion

Cite This Study

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