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April 3, 2026Food Science and Human Wellness0 citationsOpen Access

Dendrobium Officinale Polysaccharides Mitigate Diet-Induced Obesity Through Lipid Metabolism...

Multi-omics Insights into the Mitigation of Diet-induced Obesity by Dendrobium officinale Polysaccharides via Gut-Adipose Tissue Axis Modulation of Lipid Droplets

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Authors

XLXiajialong LiSYShenji YangXHXiaojun Huang

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Overview

Multi-omics study reveals Dendrobium officinale polysaccharides improve obesity by modulating lipid droplets and gut microbiota.

Key Points

  • This research aims to investigate how Dendrobium officinale polysaccharides affect diet-induced obesity and the related mechanisms.
  • Utilized a high-fat diet-induced obesity mouse model
  • Conducted transcriptomic and metagenomic analyses
  • Performed meta-analysis of adipose tissue gene expression
  • Used untargeted metabolomics to analyze serum metabolites
  • Integrated multi-omics data for a comprehensive understanding.
  • Dendrobium officinale polysaccharides significantly reduced lipid droplet expansion in white adipose tissue
  • Downregulated PLIN2 and PLIN3 genes associated with obesity
  • Activated the Wnt signaling pathway leading to reduced lipid synthesis and storage
  • Reversed gut microbiota dysbiosis by modifying gut bacteria
  • Reshaped serum metabolite profiles, increasing acylcarnitines correlated with improved metabolic parameters.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f645a333a821460e8dfhttps://doi.org/10.26599/fshw.2026.9250999
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