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March 23, 2016CirculationOpen Access

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension

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Population

Humans with Pulmonary Arterial Hypertension (PAH) and murine models

Design

Other

Authors

EBEvan L. BrittainMTMegha TalatiJFJoshua P. Fessel

Discussion

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Overview

FA metabolic defects may mark RV lipotoxicity in PAH; hypothesis-generating and requires prospective validation before targeting.

Structured PICO

P
Population
Humans with Pulmonary Arterial Hypertension (PAH) and murine models
O
Outcome
Fatty acid metabolism abnormalities, cardiac steatosis, and lipotoxicitysurrogate

Fatty acid metabolic defects are linked to right ventricular lipotoxicity and steatosis in human pulmonary arterial hypertension.

Cite This Study

Brittain et al. (2016) studied this question.

synapsesocial.com/papers/69cff5fb281d0e298e27f9f1https://doi.org/10.1161/circulationaha.115.019351
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