Fatty acid metabolic defects are linked to right ventricular lipotoxicity and steatosis in human pulmonary arterial hypertension.
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FA metabolic defects may mark RV lipotoxicity in PAH; hypothesis-generating and requires prospective validation before targeting.
Abnormalities in FA metabolism can be detected in the blood and myocardium in human PAH and are associated with in vivo cardiac steatosis and lipotoxicity. Murine data suggest that lipotoxicity may arise from reduction in FA oxidation.
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Brittain et al. (2016) studied this question.
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