Fractions from Larrea tridentata with anti-HIV-1 activity (specifically, inhibition of HIV Tat transactivation) were analyzed by GC/MS and NMR and found to contain lignans 1a-i and 2a-d. Assay-guided purification by countercurrent chromatography established 1g (mal.4) to be especially active. Compounds 1b-f, h, i and 2d are new.
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Gnabre et al. (1995) studied this question.
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