A transmission assay shows anti-CelTOS antibodies blocking P. falciparum transmission in mice, suggesting new intervention strategies.
This study establishes a luciferase-based in vivo transmission assay using an hRBC-NSG humanized mouse model for quantitative evaluation of P. falciparum transmission to mosquitoes. The platform enables functional assessment of antibody-mediated transmission-blocking activity under physiologically relevant conditions. Using this system, anti-CelTOS mAbs demonstrated inhibitory effects on parasite transmission. This assay provides a useful tool for evaluating transmission-blocking interventions and may support the development of vaccines and therapeutics aimed at reducing malaria transmission.
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Xu et al. (2026) studied this question.
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