In vitro investigation shows that testicular cell-conditioned medium supports germ cell differentiation, suggesting promising applications for reproductive biology.
The addition of TCCM, which contains extracellular matrix (ECM) proteins, enhanced in vitro differentiation of male germ cells into sperm-like structures, together with somatic cells from the genital ridge. These ECM proteins contribute to creating a microenvironment that closely mimics in vivo conditions.
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Prasetyaningtyas et al. (2025) studied this question.
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