Label-Free Optical Detection of Protein Acetylation using UV-Vis Charge Transfer Spectra

Q: What does this research mean for the field?

Protein acetylation in solution can be detected label-free using UV-Vis Protein Charge transfer spectra (ProCharTS). Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Himanshi M. Devi; Apoorva Badaya; Arijit Maity; Simangka Bor Saikia; Ravindra Venkatramani; Rajaram Swaminathan

doi:10.1039/d5sc09293k

January 1, 2026Chemical ScienceOpen Access

Label-Free Optical Detection of Protein Acetylation using UV-Vis Charge Transfer Spectra

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Key Points

The research aims to develop a method for detecting protein acetylation using UV-Vis charge transfer spectra.
Utilized UV-Vis spectroscopy to analyze protein samples in solution.
Employed charge transfer spectra to identify acetylated proteins.
Investigated the effects of acetylation on protein function and interactions.
Successfully detected acetylated proteins in solution using the UV-Vis method.
Demonstrated that this technique can reveal the presence of specific post-translational modifications.
Established a new approach for monitoring cellular processes associated with protein acetylation.

Implication

Spectroscopic detection of protein acetylation in solution, indicating an innovative approach to monitor cellular processes.

Abstract

We report the first spectroscopic detection of protein acetylation in solution using UV-Vis Protein Charge transfer spectra (ProCharTS). Acetylation is an important post-translational modification (PTM) that modulates diverse cellular processes,...

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Cite This Study

Devi et al. (2026) studied this question.

synapsesocial.com/papers/69d0aefd659487ece0fa4d28 https://doi.org/10.1039/d5sc09293k

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Label-Free Optical Detection of Protein Acetylation using UV-Vis Charge Transfer Spectra

Key Points

Implication

Abstract

Discussion

Cite This Study

Label-Free Optical Detection of Protein Acetylation using UV-Vis Charge Transfer Spectra

Key Points

Implication

Abstract

Discussion

Cite This Study

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