Key result
Age 60 and older is linked to ~35% greater interstitial fibrosis versus younger cadaveric hearts.
Observational (n=15)
Histological analysis of cadaveric hearts demonstrates that myocardial interstitial and perivascular fibrosis can be reliably quantified and are significantly more extensive in older individuals.
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Myocardial fibrosis assessment requires age adjustment in practice; confirms its progressive rise and supports targeted preventive research.
Masson's trichrome staining of cadaver hearts is a valuable tool for demonstrating the extent of myocardial fibrosis. Both interstitial and perivascular fibrosis were demonstrated, and these were more extensive in the older age groups and more pronounced around intramural vessels, highlighting the role of microvascular changes in heart disease. This work shows that using cadaveric tissue models to quantify myocardial fibrosis is practical and can aid anatomical and pathological research.
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Patra et al. (2026) conducted an observational in Myocardial fibrosis (n=15). Age ≥ 60 years vs. Age < 60 years was evaluated on Interstitial fibrosis (mean area fraction %) (p=0.004). Cadaveric hearts aged 60 years and older demonstrated significantly higher interstitial fibrosis (21.1% vs 15.6%) and perivascular fibrosis (14.9% vs 10.3%) compared to younger hearts.
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