What question did this study set out to answer?

Investigate the relationship between the CRISPR/Cas system and antibiotic resistance genes in Klebsiella pneumoniae.

April 4, 2026Future Microbiology0 citations

Association of CRISPR/Cas system with integrons and antibiotic resistance in Kliebsiella pneumoniae

MEMohamed Mohamed Adel El-SokkaryMansoura University IAIftikhar AliMansoura University

Key Points

Investigate the relationship between the CRISPR/Cas system and antibiotic resistance genes in Klebsiella pneumoniae.
Analyzed antibiotic resistance genes in Klebsiella pneumoniae isolates.
Used BOX-PCR to categorize isolates and determine CRISPR positivity.
Statistical analyses conducted to assess correlations between CRISPR and antibiotic resistance.
Measured quantities of detected genes across different BOX-PCR groups.
Significant correlation found between antibiotic resistance genes and cas genes (p = 0.0023).
BOX-PCR group A had fewer CRISPR positive isolates compared to other groups (p = 0.046).
Group A also had a limited number of detected antibiotic resistance genes.

Abstract

Antibiotic resistance genes were mostly correlated with CRISPR genes. Interestingly, BOX-PCR group A, with a lower number of CRISPR positive isolates (p = 0.046) had a limited number of detected genes, compared with other groups indicating a significant correlation between antibiotic resistance genes and cas genes (p = 0.0023).

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