Prolonged Dual Hypothermic Oxygenated Machine Perfusion for Daytime Liver Transplant

Q: What does this research mean for the field?

Routine implementation of prolonged dual hypothermic oxygenated machine perfusion (DHOPE-PRO) increases the proportion of daytime liver transplants and improves surgical logistics while maintaining clinical outcomes similar to short-duration DHOPE. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Silke B. Bodewes; Linda C. Woltjes; Adam M. Thorne; Janina Eden; Veerle A. Lantinga; Bianca Lascaris; Hans Blokzijl; Suomi M.G. Fouraschen; Hermien Hartog; Jaap Jan Vos; Ton Lisman; Vincent E. de Meijer; DHOPE-PRO Investigators; Marieke T. de Boer; Carlijn I. Buis; Suomi M.G. Fouraschen; Hermien Hartog; Frederik J.H. Hoogwater; Vincent E. de Meijer; Joost M. Klaase; Ruben H.J. de Kleine; Mark Meerdink; Maarten W. Nijkamp; Hans Blokzijl; Frans J.C. Cuperus; Frans van der Heide; Daphne M. Hotho; Frederike GI van Vilsteren; A. Boudewijn de Vries; Ilhama F. Abbasova; Jop van den Berg; Jan-Willem H.L. Boldingh; Meine H. Fernhout; Manon W.J. van der Heijden; Ernesto R.R. Muskiet; Koen M.E.M. Reyntjens; Jaap Jan Vos; Miriam Zeillemaker; Isabel M.A. Brüggenwirth; Veerle A. Lantinga; Bianca Lascaris; Adam M. Thorne; Silke B. Bodewes; Ton Lisman; Wouke Kuiper; Vivianne Veenma; Minou de Bree; Kirsten F. Ma; Roman Kalashnik; Giel van Vliet; Kees Wieriks; Carin Biel; C. Willemijn Binnekamp

doi:10.1001/jamanetworkopen.2026.5039

April 2, 2026JAMA Network OpenOpen Access

Prolonged Dual Hypothermic Oxygenated Machine Perfusion for Daytime Liver Transplant

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Key Points

This study aims to evaluate the effects of prolonged dual hypothermic oxygenated machine perfusion (DHOPE) on daytime liver transplants.
Conducted as a prospective cohort study
Implemented routine DHOPE-PRO in liver transplant procedures
Compared outcomes with short-duration DHOPE
Increased daytime liver transplants observed
Improved surgical logistics reported
Outcomes after prolonged DHOPE similar to short-duration DHOPE

Implication

Prospective cohort study shows improved outcomes with prolonged DHOPE in daytime liver transplants, suggesting clinical benefits.

Abstract

In this prospective cohort study, routine implementation of DHOPE-PRO was associated with increased proportions of daytime liver transplants and with improved surgical logistics. It was also associated with outcomes similar to those after short-duration DHOPE, supporting its broader application in clinical practice.

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Cite This Study

Bodewes et al. (2026) studied this question.

synapsesocial.com/papers/69d0aff2659487ece0fa60cf https://doi.org/10.1001/jamanetworkopen.2026.5039

View Full Paper

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Prolonged Dual Hypothermic Oxygenated Machine Perfusion for Daytime Liver Transplant

Key Points

Implication

Abstract

Discussion

Cite This Study

Prolonged Dual Hypothermic Oxygenated Machine Perfusion for Daytime Liver Transplant

Key Points

Implication

Abstract

Discussion

Cite This Study

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