Key result
Grade 2-3 uptake in asymptomatic ATTR cardiac amyloidosis linked to higher CV events and mortality.
Observational
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Asymptomatic ATTR cardiac amyloidosis patients with grade 2 or 3 uptake have higher cardiovascular event and mortality rates, suggesting they may be candidates for disease-modifying treatments.
This study shows that asymptomatic ATTR cardiac amyloid infiltration encompasses a wide spectrum of disease severity, with patients with grade 2 or 3 cardiac uptake experiencing an increased rate of CV events and CV mortality and patients with grade 1 uptake experiencing a lower CV event rate and predominantly non-CV mortality. These findings support the use of disease-modifying treatments in asymptomatic patients with grade 2 or 3 uptake and highlight the need of large-scale studies to assess their role in grade 1 uptake.
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Porcari et al. (2025) conducted an observational in Asymptomatic ATTR cardiac amyloid infiltration. Grade 2 or 3 cardiac uptake vs. Grade 1 cardiac uptake was evaluated on Cardiovascular events and cardiovascular mortality. Asymptomatic ATTR cardiac amyloid infiltration with grade 2 or 3 cardiac uptake was associated with an increased rate of cardiovascular events and mortality compared to grade 1 uptake.
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