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April 5, 2026SHILAP Revista de lepidopterologíaOpen Access

Hyperfunctioning distant metastases in high-grade differentiated thyroid carcinoma arising from HRAS-mutated follicular thyroid carcinoma: a case report and literature review

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Authors

JPJ I Y O N G PARKSYSu Woong YooSKSung Sun Kim

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Overview

Case report reveals effective radioactive iodine therapy for hormone-producing metastases in differentiated thyroid carcinoma, indicating treatment potential.

Key Points

  • This research aims to explore hyperfunctioning distant metastases in high-grade differentiated thyroid carcinoma related to HRAS mutations.
  • Case report of a 68-year-old woman with a thyroid nodule and pulmonary nodules.
  • Histopathology confirmed high-grade differentiated thyroid carcinoma from follicular thyroid carcinoma.
  • Next-generation sequencing identified the HRAS Gln61Arg mutation.
  • Whole-body radioiodine scans and follow-up CT scans were performed to evaluate treatment response.
  • Post-therapeutic scans showed iodine-avid pulmonary nodules and a left iliac bone lesion.
  • After two radioactive iodine treatments, thyroid function shifted from hyperthyroidism to hypothyroidism.
  • Follow-up CT revealed significant reduction of pulmonary metastatic lesions.

Cite This Study

PARK et al. (2026) studied this question.

synapsesocial.com/papers/69d1fb20a79560c99a0a1968https://doi.org/10.3389/fendo.2026.1817448
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