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April 5, 2026European Urology Oncology2 citationsOpen Access

Unveiling the Clinical Potential of Prostate Cancer Three-dimensional Models: A Systematic Review

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APArthur PeyrottesNBNorbert De BrekAAAnne-Sophie Vieira Aleixo

Key Points

  • This research aims to explore the potential of prostate cancer 3D models for studying tumor biology and drug responses.
  • Conducted a systematic review of existing literature on prostate cancer 3D models.
  • Focused on the application of these models in understanding tumor biology and predicting treatment outcomes.
  • Evaluated challenges related to standardization and scalability.
  • Prostate cancer 3D models can effectively predict drug responses.
  • Identified organoids as viable candidates for precision oncology.
  • Noted significant challenges in standardization that need addressing for broader application.

Abstract

Prostate cancer 3D models offer a relevant, patient-specific platform to study tumor biology, predict drug responses, and identify novel biomarkers. While standardization and scalability challenges persist, organoids have a strong potential for integration into precision oncology pipelines.

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Cite This Study

Peyrottes et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc28a79560c99a0a1c5ahttps://doi.org/10.1016/j.euo.2026.03.007
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