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Systematic review investigates mechanisms behind diabetes prevention programs, suggesting a need for clearer evidence.
Few DPP studies investigate why these interventions work. There is no compelling evidence to support any specific MMM in DPPs, and no evidence to suggest that weight loss is what causes benefits. The included studies were of good methodological quality, but tests of mechanisms were rarely pre-registered; 46% of the included studies were drawn from three datasets.
Berman et al. (2026) studied this question.
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