Research identifies how pericytes regulate capillary responses during increased neuronal activity, suggesting new insights into brain function.
We identify a previously uncharacterized adenosine-pannexin1 signaling axis in pericytes linking neuronal excitability to capillary relaxation. This mechanism provides a molecular substrate for activity-dependent capillary regulation and supports a role for pericyte pannexin1 in adenosine-mediated neurovascular responses during states of elevated metabolic demand.
No takes yet. Share an insight, caveat, or question.
Irigoyen et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: