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April 5, 2026Cancer Research

Abstract 3056: Inhibition of oncogenic phenotypes by hexanoate in triple-negative breast cancer

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Authors

NYNahara Yupe-MuñizSASamira B.F. Abdullah-VargasOLOscar A. Loperena-González

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Overview

Evaluates hexanoate's effects on cancer behavior in triple-negative breast cancer, suggesting it could provide new treatment options.

Key Points

  • To evaluate the impact of hexanoate on oncogenic phenotypes in the TNBC cell line MDA-MB-231.
  • Cultured MDA-MB-231 cells in RPMI-media under specific conditions.
  • Measured cell viability with AlamarBlue after treatment with hexanoate at varying concentrations.
  • Assessed cell proliferation using TrypanBlue to count changes over time after hexanoate treatment.
  • Evaluated cell migration with a scratch assay, measuring wound closure at multiple time points.
  • Hexanoate reduced cell viability significantly, with an IC50 of 29mM at all time points measured.
  • No significant changes in cell proliferation observed at 24h and 48h, but a significant decrease noted at 72h (p=0.004).
  • Significant reduction in wound closure at 48h (p=0.002), indicating decreased cell migration.

Cite This Study

Yupe-Muñiz et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc8ea79560c99a0a21b3https://doi.org/10.1158/1538-7445.am2026-3056
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