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April 5, 2026Cancer Research

Abstract 3502: Loss of histone 3 lysine 9 trimethylation drives recurrence in high-risk pediatric medulloblastoma

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Authors

JDJohn DeSistoADAndrew M. DonsonBVBethany Veo

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Overview

This analysis uncovers the role of H3K9me3 loss in driving recurrence in pediatric Group 3 medulloblastoma, suggesting critical therapeutic implications.

Key Points

  • The research aims to explore how loss of H3K9me3 contributes to recurrence in pediatric Group 3 medulloblastoma.
  • Developed treatment-resistant cell lines and orthotopic PDX mouse models of G3 MB.
  • Analyzed primary-recurrent patient sample pairs using single-cell RNA-Seq and multiomics.
  • Conducted spatial transcriptomics to examine changes in tumor microenvironment during recurrence.
  • Most cell types are conserved during recurrence, with increases in mesenchymal and hypoxic cells.
  • G3 MB cells exhibit treatment-resistant characteristics and enhanced DNA repair pathways after cisplatin treatment.
  • Loss of H3K9me3 correlates with increased expression of pluripotency genes during recurrence.

Cite This Study

DeSisto et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc8ea79560c99a0a2320https://doi.org/10.1158/1538-7445.am2026-3502
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 1419: Integrated spatial and genetic lineage tracing uncovers cell state plasticity underlying recurrence in group3 and group4 medulloblastoma.2026
  2. 2Abstract 2848: MYC and TGFβ promote group 3 medulloblastoma tumor resistance through deregulation of Polycomb targets2024
  3. 3Abstract PR-011: The role of tumor microenvironment in metastasis and relapses of medulloblastoma using immunocompetent mouse models2024
  4. 4Abstract B001: Glioblastoma evolution and resistance is mediated by a shift in cell state and tumor microenvironmental interactions2024
  5. 5Abstract 1736: Elucidating the oncogenic mechanisms in diffuse midline glioma: Comparative analysis of h3k27m mutation and k27 methylation loss on gene expression profiles via RNA sequencing2024