Observations on the efficacy of italicRougan Qingfei Decoction /italic（柔肝清肺方） in treating idiopathic pulmonary fibrosis and its effects on serum TGF-1，COL-I，and -SMA levels

Key Points

• The aim is to evaluate the clinical efficacy of Rougan Qingfei Decoction in patients with idiopathic pulmonary fibrosis and analyze its underlying mechanisms.
• 80 idiopathic pulmonary fibrosis patients were randomly divided into two groups, each with 40 patients.
• The control group received basic medicine and prednisone treatment.
• The observation group received basic medicine along with Rougan Qingfei Decoction.
• Both groups underwent an 8-week treatment course.
• Serum levels of TGF-β1, α-SMA, and COL-I were compared before and after treatment.
• The total effective rate in the observation group was significantly higher than in the control group (P<0.05).
• Serum levels of TGF-β1, α-SMA, and COL-I decreased significantly in both groups after treatment (P<0.01) with no statistically significant difference between groups (P>0.05).
• Both groups had an adverse reaction rate of 12.5% (5/40) with no severe adverse reactions noted.