miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences

Bruna De Felice; Ersilia Nigro; Maria Amicone; Antonio Pisani; Aurora Daniele; Federica Farinella

doi:10.1080/17501911.2026.2652277

April 2, 2026Epigenomics

miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences

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Key Points

The aim is to explore miRNA expression patterns in individuals without PKD1 or PKD2 mutations.
Profile miRNA expressions in a cohort lacking PKD1/PKD2 mutations
Analyze common and differing signatures related to ADPKD
Examine dysregulation pathways associated with miRNA
Identified significant miRNA dysregulation in mutation-negative PKD cohort
Revealed common pathways shared between PKD1 and PKD2 mutations
Highlighted potential of miRNAs as biomarkers and therapeutic targets for ADPKD

Implication

MiRNA profiling identifies dysregulation in mutation-negative ADPKD, suggesting potential biomarkers and therapies.

Abstract

The results indicate that miRNA dysregulation is present in the absence of identifiable PKD1/PKD2 mutations, supporting the idea of common pathways and highlighting the translational potential of miRNAs as biomarkers or therapeutic targets.

Discussion

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Cite This Study

Felice et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcc0a79560c99a0a2596 https://doi.org/10.1080/17501911.2026.2652277

View Full Paper

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miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences

Key Points

Implication

Abstract

Discussion

Cite This Study

miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences

Key Points

Implication

Abstract

Discussion

Cite This Study

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