Key result
Peripheral nerve block with sedation linked to ~63% less hypotension requiring inotropes versus spinal anesthesia.
Why the study?
No study had evaluated peripheral nerve block as the primary anesthetic technique in adult hip fracture surgery.
Does peripheral nerve block with sedation improve peri-operative outcomes compared to spinal anesthesia in adult patients undergoing emergency hip fracture surgery?
Does peripheral nerve block with sedation improve peri-operative outcomes compared to spinal anesthesia in adult patients undergoing emergency hip fracture surgery?
Peripheral nerve block with sedation is a feasible and safe primary anesthetic technique for emergency hip fracture surgery, with a high success rate and lower risk of intra-operative hypotension compared to spinal anesthesia.
May offer hemodynamic benefit versus spinal in hip fracture surgery but should not yet change practice; hypothesis-generating pending randomized trials.
Background: No study has evaluated peripheral nerve block as the primary anesthetic technique in adult hip fracture surgery. This retrospective cohort study compares peri-operative outcomes between spinal anesthesia and peripheral nerve block with sedation (block-sedation) in adult emergency hip fracture surgery. Methods: Adult patients who underwent hip fracture repair at Fleury Hospital between 2018 and 2025 were screened ( n = 503). Of these, patients receiving planned spinal anesthesia ( n = 238) or block-sedation ( n = 230) were identified. Primary outcome was the success rate of block-sedation in emergency hip fracture surgery, defined as the proportion of patients in whom block-sedation was used without conversion to another anesthetic technique. Secondary outcomes included peri-operative opioid requirement (MME), postoperative pain, intra-operative anesthetic requirements (i.e., ketamine, midazolam, propofol), post-anesthesia care unit (PACU) stay, hospital length of stay, and intra-operative hypotension requiring inotropes. Results: Block-sedation was successful without conversion in 98.1% of patients; four patients (1.9%) required conversion to general anesthesia and were excluded from peri-operative outcomes. Median PACU stay was longer in the spinal group (54 min, IQR 42–72) compared with block-sedation (36 min, IQR 27–53; P < 0.001) The incidence of hypotension requiring inotropes was higher in the spinal group (53.0%) compared with the block-sedation group (19.4%; P < 0.001). Postoperative pain scores were comparable between groups ( P = 0.126), and postoperative hospital length of stay was also similar ( P = 0.416). Conclusion: In this propensity-matched cohort study, block-sedation was feasible and safe for MIS hip fracture surgeries, with a high success rate (>98%) and low conversion to general anesthesia.
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Low et al. (2026) studied this question. Peripheral nerve block with sedation achieved a 98.1% success rate in hip fracture surgery and reduced hypotension requiring inotropes to 19.4% versus 53.0% with spinal anesthesia.
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