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April 5, 2026Cancer Research0 citations

CXCL17 Mediates Angiogenesis In Cutaneous Squamous Cell Carcinoma

Abstract 4796: CXCL17 Drives angiogenesis to promote progression in cutaneous squamous cell carcinoma

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Authors

AKAlok R. KhandelwalCNCherie-Ann NathanKJKeerthan Jaganmohan

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Overview

This investigation reveals CXCL17's role in promoting angiogenesis in cutaneous squamous cell carcinoma, suggesting new treatment avenues.

Key Points

  • The research aims to elucidate the role of CXCL17 in angiogenesis and tumor progression in cutaneous squamous cell carcinoma.
  • Conducted molecular analyses on human microvascular endothelial cells treated with CXCL17.
  • Utilized a syngeneic tumor-cell xenograft model to validate the findings.
  • Performed clinical correlation studies to assess CXCL17 expression and its association with tumor aggressiveness.
  • CXCL17 treatment leads to significant activation of oncogenic and angiogenic pathways.
  • Intensified phosphorylation of eNOS and AKT, enhancing endothelial cell survival and nitric oxide production.
  • CXCL17-knockout tumors showed reduced CD31 staining, indicating decreased angiogenesis.
  • Higher CXCL17 expression correlates with increased perineural invasion and tumor aggressiveness.

Cite This Study

Khandelwal et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd13a79560c99a0a2d62https://doi.org/10.1158/1538-7445.am2026-4796
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