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April 5, 2026Cancer Research

Myeloma Cells with Therapy-Induced Senescence Are Associated with Resistance to CAR-T Therapy

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Authors

SASofia ArbelaezACAndre de Menezes Silva CorraesGBGabriel Álvares Borges

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Overview

Investigates therapy-induced senescence in myeloma cells and its association with CAR-T therapy resistance.

Key Points

  • Examine the presence of therapy-induced senescence-like phenotype in myeloma cells prior to CAR-T therapy and its association with treatment response.
  • Analyzed single-cell RNA sequencing (scRNA-seq) data from bone marrow myeloma cells
  • Conducted single-cell gene set enrichment analysis (scGSEA) for senescence-related gene sets
  • Stained bone marrow myeloma cells for specific surface markers and analyzed them using flow cytometry
  • Late-stage myeloma cells showed higher enrichment of senescence-related gene sets compared to newly diagnosed cases
  • An inverse correlation was observed between senescence marker expression and progression-free survival after CAR-T therapy
  • High percentage of CD14+ myeloma cells were detected in a significant portion of patients

Cite This Study

Arbelaez et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd13a79560c99a0a2e60https://doi.org/10.1158/1538-7445.am2026-6467
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6475: Myeloma cells with therapy-induced senescence-like phenotype have increased resistance to killing by T cell directed therapies2026
  2. 2Abstract 2958: Melphalan-treated multiple myeloma cells exhibit a senescent-like dormancy phenotype2024
  3. 3Evidence for pre-existing myeloma cells with a gene expression pattern associated with resistance to BCMA CAR T cells.2025
  4. 4Highlighted Research Articles2026
  5. 5Abstract 3980: Non-canonical CAR T cell states correlate with durable therapeutic responses in multiple myeloma patients2026