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April 5, 2026ChemistrySelect0 citations

New N-Acylhydrazone Isatin/Benzofuran Scaffold for Colorectal Cancer

Discovering a New N ‐acylhydrazone Tethered Isatin/Benzofuran Scaffold for Colorectal Cancer: Design, Synthesis, Biological Activity, and ADME‐ Tox Modelling

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Authors

CZCristian J. Zambrano‐ForeroSASantiago M. ArangoAHAngie Herrera‐Ramírez

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Overview

Discovers a novel compound showing significant anticancer effects in colorectal cancer, suggesting a potential new treatment strategy.

Key Points

  • The aim is to design and evaluate a new series of hybrid molecules for colorectal cancer treatment.
  • Synthesis of hybrid molecules by linking isatin and benzofuran through N-acylhydrazone.
  • Biological evaluation on colorectal adenocarcinoma cells (SW480) and nonmalignant cells (NCM460).
  • Assessment of cytotoxic and antiproliferative effects of synthesized compounds.
  • In silico ADME analysis to predict biopharmaceutical profiles.
  • A brominated isatin-benzofuran derivative showed significant cytotoxicity and antiproliferative activity.
  • The compound was more effective than the reference drug 5-fluorouracil.
  • The hybrid exhibited slight selectivity toward cancer cells with evidence of programmed cell death.
  • Morphological changes indicated potential mitochondrial-dependent cell death.
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Cite This Study

Zambrano‐Forero et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd29a79560c99a0a3023https://doi.org/10.1002/slct.202504507
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel benzofuran/pterostilbene hybrids trigger programmed cell death and impair migration in CRC cells2026
  2. 2The Suppressive Effect of Novel Hydrazones‐Tethered Imidazoles in HCT‐116 and HT‐29 Colorectal Cancer Cells: Synthesis, Biological Activity and Molecular Modeling Studies2024
  3. 3Design, Synthesis, and <i>In Silico</i> and <i>In Vitro</i> Cytotoxic Activities of Novel Isoniazid–Hydrazone Analogues Linked to Fluorinated Sulfonate Esters2024 · 3 citations
  4. 4Synthesis, Biological Investigation, and Molecular Docking of Novel Benzimidazole‐Hydrazone Hybrids as Potential Anticancer Agent Candidates2024 · 2 citations
  5. 5Benzofuran-isatin derivative 5d acts as a dual-action agent in colorectal cancer cells by targeting EMT and mitochondrial apoptosis pathways2026