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April 5, 2026Cancer Research

Abstract 1275: Phospholipase D1 overexpression drives metabolic survival and stress resistance in cervical cancer.

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Authors

SKSung Wan KangDKDong Woo KangYNYu-na Noh

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Overview

Researchers explore how phospholipase D1 affects survival in cervical cancer, highlighting its potential as a therapeutic target.

Key Points

  • This research investigates the role of phospholipase D1 (PLD1) in driving metabolic resistance and survival in cervical squamous cell carcinoma (SCC).
  • Evaluated PLD1 expression using TCGA datasets and validated with primary cervical tumors through qRT-PCR, PLD activity assays, and immunohistochemistry.
  • Conducted functional studies with PLD1 knockdown via shRNA and a selective inhibitor in primary SCC and adenocarcinoma cells.
  • Measured apoptosis, ATP levels, glycolytic activity, clonogenic survival, and invasion under both normal and metabolic stress conditions.
  • PLD1 was significantly overexpressed in SCC compared to adenocarcinoma at mRNA, protein, and enzymatic levels.
  • Inhibition of PLD1 led to decreased survival rates in SCC cells, while ADC cells showed minimal sensitivity.
  • Blocking PLD1 reduced glycolytic flux and ATP production and resulted in increased apoptosis under metabolic stress conditions.
  • PLD1 knockdown negatively affected clonogenic survival and invasion in SCC cells.

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd29a79560c99a0a30d4https://doi.org/10.1158/1538-7445.am2026-1275
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6492: Targeting phospholipase D1 overcomes platinum resistance and enhances cisplatin efficacy in ovarian cancer2026
  2. 2Abstract 3356: Inhibiting phospholipase D1 reduces pancreatic carcinogenesis in mice2024
  3. 3Abstract 7006: Inhibiting intracellular cPLA2α in cervical cancer cells enhances antitumor immunity and facilitates the efficacy of anti-PD1 checkpoint immunotherapy2026
  4. 4Abstract 2026: Scd1 overexpression in cancer-associated adipocytes drives breast cancer development and metastasis.2026
  5. 5Abstract 3059: Targeting metabolic dependencies in MYC-driven osteosarcoma through Lp-PLA2 inhibition2026