To investigate glucagon levels in individuals with newly diagnosed type 2 diabetes and steatotic liver disease.
Measured glucagon concentrations postprandially in subjects with type 2 diabetes and steatotic liver disease.
Evaluated insulin sensitivity among participants.
Analyzed the role of glucagonotropic metabolites in relation to glucagon levels.
Higher glucagon concentrations observed in early postprandial states.
No significant difference in insulin sensitivity compared to controls.
Findings imply the presence of hepatic glucagon resistance.
Abstract
Hyperglucagonemia in the face of higher HLC in early T2D is not due to differences in insulin sensitivity or glucagonotropic metabolites but could suggest hepatic glucagon resistance.