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April 5, 2026Cancer Research

Abstract 2631: LPD002, a novel anti-PD-1/IL-2 fusion protein, demonstrates potent antitumor activity in preclinical studies.

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Authors

XZXiaoli ZhangZCZhijian CaiSLShuo Liu

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Overview

Preclinical studies demonstrate LPD002 enhances anti-tumor efficacy in PD-1 models, suggesting a promising therapeutic approach.

Key Points

  • This research aims to evaluate the efficacy and safety of LPD002, an engineered fusion protein for cancer treatment.
  • Engineered LPD002 combining anti-PD-1 antibody and IL-2 mutein.
  • Assessed functionality through PD-1 blockade and IL-2 signaling assays.
  • Evaluated anti-tumor activity in PD-1 humanized mouse models.
  • Analyzed pharmacokinetics in cynomolgus monkeys.
  • LPD002 induced enhanced pSTAT5 signaling in PD-1-expressing cells.
  • Activated CD4+ and CD8+ T cells in human PBMCs.
  • Demonstrated superior anti-tumor efficacy in PD-1-sensitive and resistant models.
  • Showed a favorable pharmacokinetic profile in cynomolgus monkeys.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd9ca79560c99a0a3c55https://doi.org/10.1158/1538-7445.am2026-2631
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