The trial shows homelessness increases while chronic pain decreases the likelihood of XR-Naltrexone initiation in patients with OUD, suggesting tailored treatments may be beneficial.
Among patients with OUD initiating treatment on inpatient units, homelessness was associated with greater likelihood of successfully initiating XR-Naltrexone, while chronic pain was associated with lower likelihood of XR-Naltrexone initiation. Future research on XR-Naltrexone initiation should consider tailoring treatment based on housing status and other social determinants, and evaluation and management of pain.
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Potter et al. (2026) studied this question.
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