Abstract 6263: Association of tumor infiltrating lymphocytes and proinflammatory biomarkers with breast cancer molecular subtypes: Analysis of the MEND study.
Analysis of tumor infiltrating lymphocytes and proinflammatory biomarkers reveals associations with breast cancer subtypes in Nigerian women, suggesting implications for immunotherapy.
Key Points
This study aims to evaluate the association of tumor infiltrating lymphocytes and proinflammatory biomarkers with breast cancer molecular subtypes in Nigerian women.
Analyzed 436 newly diagnosed, treatment-naïve breast cancer patients from Nigeria.
Characterized breast cancer molecular subtypes using immunohistochemistry.
Quantified tumor infiltrating lymphocytes on H&E-stained slides as per International TILs Working Group criteria.
Assessed serum levels of proinflammatory biomarkers (e.g., IL-6, TNF-α) using immunoassays.
Utilized multivariable logistic and multinomial regression to determine associations.
43% of tumors were TNBC subtype; 52.8% were grade 2 or 3 tumors.
Median TIL percentage was 10.0%, with 49% categorized as low.
High TIL levels were associated with approximately 5-fold higher odds of being diagnosed with TNBC.
Increased TNF-α levels correlated significantly with higher odds of TNBC after adjustments.