What question did this study set out to answer?

The aim is to investigate the expression of MLK4 in colon cancer and its correlation with patient survival outcomes.

Association Between MLK4 Expression and Survival in Colon Cancer

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In-silico analysis evaluates MLK4 expression and its association with survival in colon cancer, suggesting potential prognostic value.

The aim is to investigate the expression of MLK4 in colon cancer and its correlation with patient survival outcomes.
Conducted in-silico analysis of MLK4 expression using TCGA databases for survival comparison.
Analyzed tumor and adjacent normal tissues using tissue microarray (TMA) and survival data.
Performed RNA quantification via RT-PCR and assessed protein levels through immunohistochemistry (IHC).
Significant increase in MLK4 protein levels observed in colon cancer compared to normal tissues (mean difference = 0.405, p < 0.05).
Moderate correlation identified between MLK4 levels in tumor and normal tissues (r = 0.4721, p < 0.0001).
MLK4 mRNA levels showed significant increase in cancer specimens (mean difference = 2.139, p < 0.05).
Higher MLK4 expression trends towards reduced overall survival (HR = 1.25, p = 0.079).
Increased MLK4 methylation correlated with poorer survival trends (HR = 1.54, p = 0.07).

Kumar et al. (2026) studied this question.

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