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April 5, 2026Diabetic Medicine

The long non‐coding RNA KDM4A ‐ AS1 protects β‐cell function via the miR ‐423‐5p/growth differentiation factor 11 axis

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Authors

YZYan ZengLSLiyu SunJLJie Li

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Overview

Demonstrates the protective role of KDM4A-AS1 on β-cell function in type 2 diabetes, suggesting new therapeutic targets.

Key Points

  • This research aims to explore how KDM4A-AS1 regulates β-cell function and its implications in type 2 diabetes.
  • Enrolled 98 T2DM patients and 91 healthy controls.
  • Measured serum and cellular factor expression using RT-qPCR.
  • Assessed cell proliferation with CCK-8, apoptosis via flow cytometry, and insulin secretion through ELISA.
  • Confirmed interactions between KDM4A-AS1, miR-423-5p, and GDF11 using RNA immunoprecipitation and dual-luciferase assays.
  • KDM4A-AS1 and GDF11 were significantly downregulated in T2DM patients' serum.
  • miR-423-5p was significantly upregulated in T2DM patients.
  • KDM4A-AS1 showed a negative correlation with fasting plasma glucose and HbAlc levels.
  • Overexpression of KDM4A-AS1 enhanced insulin gene expression, insulin secretion, and cell proliferation while reducing apoptosis.

Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/69d1fde4a79560c99a0a4479https://doi.org/10.1111/dme.70309
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