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April 5, 2026Cancer Research

Abstract 6609: Targeting pancreatic cancer with combination RAS inhibition and radiation therapy.

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Authors

CTCandise TatKRKimal RajapaksheERE. Rodriguez

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Overview

This research demonstrates targeting cuproptosis enhances radiation therapy efficacy in pancreatic cancer, suggesting new treatment pathways.

Key Points

  • The aim is to explore how RAS inhibition combined with radiation therapy can overcome radioresistance in pancreatic cancer.
  • Injected KPC cancer cells into the pancreas of mice and administered radiation therapy.
  • Conducted single-cell RNA sequencing to assess gene expression post-radiation.
  • Evaluated effects of a pan-RAS inhibitor on cell viability and gene expression.
  • Modified cuproptosis defense genes to understand their role in mediating cell death.
  • Recurrent tumors showed increased expression of metallothioneins, correlating with radioresistance.
  • Higher levels of metallothioneins linked to reduced free copper pools in resistant lesions.
  • iRAS treatment increased lipoylated protein levels, enhancing the susceptibility of cancer cells to radiation.
  • Overexpression of CTR1 in PDAC cells made them more sensitive to radiation when combined with copper and iRAS.

Cite This Study

Tat et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe18a79560c99a0a48aehttps://doi.org/10.1158/1538-7445.am2026-6609
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 699: Targeting radiation-driven invasion and metastasis in pancreatic cancer2024
  2. 2Abstract A009: Synergistically overcoming KRAS-driven radioresistance and immune evasion in PDAC with alpha particle radiotherapy and anti-CTLA-42026
  3. 3Abstract 1871: Combined RAS and ICB inhibition targets NF-KB-driven immune evasion in chemoresistant pancreatic cancer.2026
  4. 4Abstract 4637: Alpha-particle radiotherapy combined with anti-CTLA-4 synergistically overcomes radioresistance and induces local and systemic antitumor immunity in PDAC2026
  5. 5Abstract A023: Combined RAS and ICB inhibition targets NF-κB–driven immune evasion in chemoresistant pancreatic cancer2026