What question did this study set out to answer?

This research aims to explore the relationship between intratissue microbiota and tumor genomic alterations in CRC.

April 5, 20260 citationsOpen Access

Intratissue microbiota of CRC

AIAnders IsakssonGoethe University Frankfurt

Puntos clave

This research aims to explore the relationship between intratissue microbiota and tumor genomic alterations in CRC.
Analyzed sequencing data from 937 CRC patients
Extracted non-human reads from genomic data
Identified 292 genera and 420 species of microbiota in tissue samples
Found a substantial diversity of tissue-resident microbiota
Identified potential links between microbiota and tumor genomic changes
Highlighted implications for prognosis in CRC patients

Resumen

Non-human reads were extracted from sequencing data of "Nunes, L. et al. 2024. Nature. https://doi.org/10.1038/s41586-024-07769-3". To deepen the understanding of intratissue microbiota in CRC and its complex interplay with tumor genomic alterations and prognosis, we here analyzed whole-genomes and transcriptomes from 937 patients with CRC, and identified 292 genera and 420 species as common tissue-resident microbiota.

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