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April 5, 2026Cancer Research

CRISPR Cas9 Screens Reveal Tumor Suppressors in Aggressive Lymphoma Mouse Model

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Authors

VMVivian M. MorrisNational Institutes of HealthJMJagan MuppidiNational Institutes of HealthLouis M. StaudtLouis M. StaudtThe Wistar Institute

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Implication

Experiments identify critical tumor suppressors in lymphoma, suggesting new therapeutic targets.

Key Points

  • The research aims to identify key tumor suppressors associated with aggressive diffuse large B cell lymphoma (DLBCL) in a mouse model.
  • Developed a murine model with genetic alterations of MCD subtype DLBCL
  • Utilized CRISPR/Cas9 for loss-of-function assays targeting candidate tumor suppressor genes
  • Conducted single-cell RNA sequencing to analyze gene expression patterns
  • Loss of Setd1b and Tbl1xr1 significantly increased premalignant germinal center B cell populations
  • Combined gene knockout accelerated tumorigenesis in MCD mice
  • Alterations in gene expression indicated dependence on oncogenic pathways in human MCD tumors

Cite This Study

Morris et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe68a79560c99a0a4b19https://doi.org/10.1158/1538-7445.am2026-598
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Also Consider

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  1. 1Abstract IA011: Ccnd1 initiates mantle cell lymphoma–like disease and cooperates with Sox11 expression and loss of Atm/Trp53 in autochthonous mouse models2026
  2. 2Abstract PR002: Bcl6 -driven Cd70 -deficient Diffuse large B-cell lymphomas originate from innate-like cells with blunted CD4+ cytotoxic T-cell immune surveillance2026
  3. 3Stepwise engineering of human germinal center B cells to model dark zone high-grade B cell lymphoma driven by sequential BCL2 and MYC deregulation2025
  4. 4Abstract PO-037: Machine learning-enabled transomics identifies three therapeutic targets for MYC-driven diffuse large B cell lymphoma2024
  5. 5Abstract 5720: Targeting CDK9 in cutaneous T-cell lymphoma using patient-derived xenograft models2024