Examines the link between GDF-15 and muscle wasting and anemia in chronic kidney disease, highlighting potential therapeutic targets.
Elevated GDF-15 is associated with muscle wasting and anemia in CKD independent of age, sex, comorbidities, and kidney function, mirroring its role in cancer cachexia. These findings suggest that GDF-15 may reflect pathophysiological processes linked to cachexia-related phenotypes and warrants further investigation as a potential therapeutic target in CKD.
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Lin et al. (2026) studied this question.
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