What question did this study set out to answer?

To develop MicroFinder for identifying and organizing scaffolds in bird dot microchromosomes to enhance genome assembly.

April 6, 2026GigaScience0 citationsOpen Access

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MicroFinder: conserved gene-set mapping and assembly ordering for manual curation of bird dot microchromosomes

TMThomas C. MathersJohn Innes Centre MPMichael PauliniWellcome Sanger Institute CSCibele G. Sotero-CaioWellcome Sanger Institute

Key Points

To develop MicroFinder for identifying and organizing scaffolds in bird dot microchromosomes to enhance genome assembly.
Developed a pipeline to map gene sets and order microchromosome scaffolds.
Applied MicroFinder to draft genome assemblies of birds.
Conducted manual curation to improve existing genome assemblies.
MicroFinder significantly increases the speed of assembly curation.
It enhances the accuracy of bird dot microchromosomes in genome assemblies.
Improvement is noted even in previously curated genome assemblies.

Abstract

We present MicroFinder, a pipeline to identify and order putative dot microchromosome scaffolds in draft genome assemblies. MicroFinder is an effective aid for bird genome assembly that dramatically speeds up manual assembly curation and improves the accuracy and sequence content of bird dot microchromosomes, even enabling improvement to genome assemblies that have already undergone expert curation.

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MicroFinder: conserved gene-set mapping and assembly ordering for manual curation of bird dot microchromosomes

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