Collagen I–DDR1 Signaling as a Driver of Keloid Inflammation: Mechanistic Expansion of the ARF6–DDR1 Axis

This letter critically evaluates the recent study by Hu et al. on collagen I–DDR1 signaling in keloid inflammation, highlighting its role in activating NF-κB and STAT3 pathways. We discuss the potential of dual-target therapy involving DDR1 and ARF6 inhibition and identify areas for further exploration, including the involvement of co-receptors, intermediate signaling pathways, and collagen remodeling. These insights may guide future therapeutic strategies for keloid treatment.