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Data set shows dose- and sex-dependent effects on lactate dehydrogenase in rat tissues, suggesting metabolic variability.
This dataset contains the results of a study of the effect of vanadium citrate on lactate dehydrogenase (LDH) activity in tissues of Wistar rats of both sexes. The study focuses on dose-dependent and sex-related features of the metabolic response of key organs (skeletal muscle, liver, kidney, and pancreas). Data Structure:The dataset is presented in Excel (.xlsx) format and consists of two main sections: Raw Data (Individual Values): Primary measurement results for each individual animal (n=6 in each experimental group). This allows us to assess the variability of the indicators within the groups. Statistical Analysis (Two-way ANOVA): Results of a two-factor analysis of variance, confirming the statistical significance of the influence of the factors "Sex", "Dose" and their interaction (Interaction). The F-test value, p-value, and partial eta-squared, η²p were calculated. Methodology Brief: Enzymatic activity: LDH activity was determined spectrophotometrically by the rate of NADH oxidation. Normalization: LDH activity was normalized to the total protein concentration determined by the Bradford method. Units: Results are presented as specific activity in µmol/(min × mg of protein). Animals: 48 Wistar rats (24 males, 24 females), 6 weeks old. Groups: Control (I) and three experimental groups (II, III, IV) receiving different concentrations of vanadium citrate for 36 days.
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Oliynyk et al. (2024) studied this question.
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